The influence of Imuniplant on the microbiome in patients with inflammatory bowel disease
Major Gheorghe GIURGIU1, Prof dr Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
https://orcid.org/0000-0002-5449-2712
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background It is now evident that the gut microbiota has a profound effect on the host immune system. The interactions between the gut microbiota and inflammatory bowel disease are complex, dynamic and context-dependent. The gut microbiota and its metabolites have been shown to influence immune homeostasis both locally and systemically. Bacterial contents such as lipopolysaccharide and bacterial antigens can induce a inflammatory bowel disease The biggest question in the field is whether inflammation causes gut dysbiosis or dysbiosis leads to disease induction or propagation.
Objectives To demonstrate role of plants in the management of inflammatory bowel disease. The direct modulation of gut microbiome that could diminish chronic inflammatory responses and ameliorate adaptive immune responses is major pathway to stabilize inflammatory bowel disease.
Materials and methods Recent reports indicate that dysbiosis is increased in inflammatory bowel disease. Plant modulation of the immune system can also have a role in the inflammatory bowel disease, acting to reduce or delay the onset of inflammatory bowel disease. Ongoing research in this field will ultimately lead to a better understanding of the role of diet and plants in chronic inflammation in patients with inflammatory bowel disease.
Results Plants may restore the composition of the gut microbiome and introduce beneficial functions to gut microbial communities, resulting in amelioration or prevention inflammatory bowel disease
Conclusion The gut microbiota is considered to be a master regulator of inflammatory bowel disease. Besides modifying the gut microbiota, plants modulates the immune system in patients with inflammatory bowel disease.
Keywords: inflammatory bowel disease, microbiome, immunomodulation, Imuniplant