MICROBIOTA MODULATION AS THERAPEUTIC APPROACH IN THE NEUROPATHIC PAIN IN DOG WITH SPINAL CORD INJURY: IMPACT OF POLENOPLASMIN

MICROBIOTA MODULATION AS THERAPEUTIC APPROACH IN THE NEUROPATHIC PAIN IN DOG WITH SPINAL CORD INJURY: IMPACT OF POLENOPLASMIN

Major Gheorghe GIURGIU¹,Prof. dr. Manole COJOCARU², SciRes I, EuSpLM

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +4 0744 827 881

https://orcid.org/0000-0002-5449-2712

²Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

Romanian Academy of Scientists

cojocaru.manole@gmail.com; Telephone: +4 0723 326 663
https://orcid.org/0000-0002-7192-7490

Background Studies have demonstrated the presence of gut dysbiosis (alterations in gut bacterial homeostasis) secondary to spinal cord injury in dogs. The dysbiosis is thought to impair recovery by decreasing the production of short-chain fatty acids which play a role in suppressing inflammation within the central nervous system.  

Objective Therefore, targeting gut dysbiosis could have significant therapeutic value in the management of spinal cord injury. The purpose of this study is to determine if gut dysbiosis occurs in dogs with spinal cord injury. Another area of potential intervention interest is in situations of spinal injury where there is an urgent need to generate new neurons. To arrive at these observations, the authors examined how Polenoplasmin and diet solve paralysis in dogs. 

Materials and methods The most common cause of spinal problems in dogs is trauma. We are currently assessing whether indoles can also stimulate formation of neurons in dogs with paralysis.

Results We found that gut microbes that metabolize tryptophan-an essential amino acid-secrete small molecules called indoles, which stimulate the development of new brain cells in dogs, also demonstrated that the indole-mediated signals elicit key regulatory factors known to be important for the formation of new neurons.

Conclusion This study is another intriguing piece of the puzzle highlighting the importance of lifestyle factors and diet. The link between the health of the microbiome and the health of the brain shows how microorganisms in the gut solve paralysis, gut microbe secreted molecule linked to formation of new nerve cells in paralyzed dogs.

Keywords: gut dysbiosis, indole, paralyzed dog, Polenoplasmin.