Microbiota Alzheimer’s disease: Impact of Polenoplasmin

Microbiota Alzheimer’s disease: Impact of Polenoplasmin

Major Gheorghe GIURGIU¹,Prof. dr. Manole COJOCARU² SciRes I, EuSpLM

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +40744827881

https://orcid.org/0000-0002-5449-2712

²The Romanian Academy of Scientists

Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com; Telephone: +40723326663
https://orcid.org/0000-0002-6871-577X

Background Disturbances along the brain-gut-microbiota axis may significantly contribute to the pathogenesis of neurodegenerative disorders. Alterations in the gut microbiota composition induce increased permeability of the gut barrier and immune activation leading to systemic inflammation, which in turn may impair the blood-brain barrier and promote neuroinflammation, neural injury, and ultimately neurodegeneration.  Nutrition is known to play an important role in the pathogenesis of Alzheimer’s disease. In addition, the use of nutraceuticals can be part of a comprehensive approach to delay neurodegeneration.

Objective There is a strong link between Alzheimer’s disease and chronic inflammation. Modification of the gut microbiota composition by nutraceuticals may create new preventive and therapeutic options in Alzheimer’s disease. To arrive at these observations, the authors examined how Polenoplasmin and diet delay neurodegeneration.

Materials and methods Imbalances in the gut microbiota can be also associated with the neurodegeneration. There is increasing interest in the role of the peripheral immune system in Alzheimer’s disease pathology. We are currently assessing whether indoles can also stimulate formation of neurons in Alzheimer’s disease.

Results It has now been shown that microbiota affects brain functions through various metabolites with potentially positive or, conversely, toxic properties. The immune system has a prominent role in Alzheimer’s disease pathogenesis with both innate and adaptive immunity in the central nervous system. 

Conclusion Alzheimer disease is a neurodegenerative disorder characterized by a progressive decline in memory and thinking severe enough to interfere with daily life. Existing evidence suggests that dietary lifestyle changes may affect cognitive function.

Keywords: gut microbiota, brain-gut-microbiota axis, Alzheimer disease, nutraceuticals