Interrelation of Imuniplant, gut microbiome, and autoantibody production
Major Gheorghe GIURGIU1, Prof dr med Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
https://orcid.org/0000-0002-5449-2712
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background B cells are involved in humoral and cell-mediated immunity. B cells secrete autoantibodies following differentiation into plasma cells. Western-diet patterns, such as high fat and high salt diets, can induce alterations in the gut microbiome.
The objective of this study was to investigate interrelation of Imuniplant, gut microbiome, and autoantibody production. Deregulation of this system could contribute to change of the production of autoantibodies.
Materials and methods A disturbed microbiome has been observed in patients with autoimmune diseases and studies have supported a possible link between Imuniplant and the microbiome.
Results We summarize knowledge on the influence of Imuniplant on B cell function and autoantibody production in relation to the gut microbiota. We describe the interrelation Imuniplant, microbiome and B cell function with a focus on the production of autoantibodies. A Western-diet lacking components of high nutrient value such as probiotics may negatively modulate immune responses, thereby leading to decreased immune tolerance as well as disease and infection progression. Dietary components such as gluten, selenium, and iodine have been shown to increase autoantibody production. Monthly consumption of fish oil by postpartum women led to lower levels of anti-thyroid autoantibodies. On the contrary, a cocoa-rich diet decreases autoantibody production and confers beneficial immune function.
Conclusion Increasing evidence is being gathered for the interplay between Imuniplant, microbiome, and autoantibody production. A Western-diet may influence the balanced composition of the gut microbiome leading to perturbed immune responses, including effects on B cell production, activity, and maturation. Autoantibody production could contribute to autoimmune diseases.
Keywords: autoantibodies, diet, microbiome, Imuniplant