Dysregulation of the dopamine system in stroke: Impact of Neuropolen
Major Gheorghe GIURGIU1, Prof dr med Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
https://orcid.org/0000-0002-5449-2712
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background A stroke can have a significant impact on the production and regulation of neurotransmitters, particularly dopamine. When a stroke occurs, it can disrupt the normal dopamine pathways, leading to movement problems such as hemiparesis or hemiplegia.
Objective Stroke, a sudden interruption of blood supply to the brain, can have devastating consequences, including physical disability and cognitive impairment. We will explore how strokes can cause an increase in the release of glutamate, leading to premature neuron death and the resulting implications for stroke recovery.
Materials and methods The impact of a stroke on dopamine levels can have far-reaching consequences for a person’s recovery and overall quality of life. Treatments that target the dopamine system, such as specific drugs and comprehensive rehabilitation programs, can be effective in improving motor function and cognitive abilities.
Results Understanding the intricate link between stroke and dopamine is essential for developing effective treatments and rehabilitation strategies. Dopamine, a crucial neurotransmitter, plays a pivotal role in various brain functions, including movement, mood, and motivation.
Conclusion The destruction of brain tissue due to oxygen deprivation or bleeding can disrupt normal dopamine pathways, resulting in movement disorders such as hemiparesis or hemiplegia.
The reduction in oxygen availability leads to a shift towards acidosis and an increase in extracellular potassium concentration, causing neural cell membrane depolarization. The excessive glutamate accumulation, which can reach up to 80 times the normal level, is believed to play a critical role in the premature death of neurons that would otherwise survive and recover.
Keywords: stroke, neurotransmiters, dopamine, Neuropolen