CLINICAL BENEFITS OF DENIPLANT NUTRITIONAL INTERVENTIONS FOR THE MANAGEMENT OF PSORIASIS

CLINICAL BENEFITS OF DENIPLANT NUTRITIONAL INTERVENTIONS FOR THE MANAGEMENT OF PSORIASIS

Major Giurgiu Gheorghe¹, Prof. dr. Cojocaru Manole²

¹Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com; Telephone: +40744827881

https://orcid.org/0000-0002-5449-2712

²Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com; Telephone: +40723326663
https://orcid.org/0000-0002-6871-577X

Background Psoriasis is a chronic inflammatory skin disease. It is also defined as an immune-mediated pathology, with cutaneous and systemic manifestations that has numerous consequences on the quality of life of patients who suffer from it. It is known that also calorie restriction and low calorie diet can improve the symptomatology and the development of psoriasis. It is known that the immune system and the microbiome are linked.

Objectives New evidences suggest that the microbiome may play a pathogenic role in psoriatic disease. The aim of the present project is to investigate whether a dietary intervention could ameliorate the clinical manifestations and modulate the gut microbiota of individuals with psoriasis.

Materials and methods Nutrition plays an important role in the development of psoriasis and it can modulate microbiota and microbiome composition.

Results Among environmental factors, diet plays a central role therefore incorrect nutritional habits and excessive body weight can increase clinical symptoms or even trigger the disease. Such diet-based and nutraceutical approaches to targeting the microbiome may produce a milder side effect profile than current systemic medications. Thus, interventions aimed at the microbiome may be a valuable adjunct for preventing or managing psoriatic disease and its comorbidities.

Conclusion Nutrition plays an important role in the development of psoriasis and its comorbidities. Ultimately, a better understanding of the psoriatic microbiome can lead to the development of new therapeutic modalities that target the shifting microbiota. Thus, interventions aimed at the microbiome may be a valuable adjunct for preventing or managing psoriatic disease and its comorbidities

Keywords: psoriasis, microbiome, microbiota, Deniplant nutritional intervention