THE GUT-BRAIN-SKIN AXIS IN ACNE: IMPACT OF POLENODERM

THE GUT-BRAIN-SKIN AXIS IN ACNE: IMPACT OF POLENODERM

1 Major Gheorghe Giurgiu

Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania

deniplant@gmail.com, 012371

https://orcid.org/0000-0002-5449-2712

2 Prof. dr. Manole Cojocaru

The Romanian Academy of Scientists

Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania

cojocaru.manole@gmail.com, 031593
https://orcid.org/0000-0002-6871-577X

Background It is increasingly believed that the interaction between skin microbes and host immunity plays an important role in acne. Acne also has close connections with the gastrointestinal tract, and many argue that the gut microbiota could be involved in the pathogenic process of acne. The emotions of stress, have been hypothesized to aggravate acne by altering the gut microbiota. The presence of a gut-brain-skin axis that connects gut microbes, oral probiotics, and diet, currently an area of intense scrutiny, to acne severity. This study concentrates on the skin and gut microbes in acne, the role that the gut-brain-skin axis plays in the immunobiology of acne, and newly emerging microbiome-based therapies that can be applied to treat acne.

Obiective The purpose of this study was to compare the diversity of the skin microbiota in acne patients before and after taking Polenoderm. 

Materials and methods A longitudinal cohort study was performed on 20 participants with moderate to severe facial acne with no recent use of oral and topical antibiotics/retinoids.

Results Hence, it is crucial to understand Polenoderm impact on the acne skin microbiota which is thought to be perturbed, our study provides insight into the skin microbiota in acne and how it is modulated by Polenoderm and diet.

Conclusion Acne also has close connections with the gastrointestinal tract, and many argue that the gut microbiota could be involved in the pathogenic process of acne. As understanding of the microbiome in healthy skin and the pathophysiology of acne continues to develop, new therapeutic targets are arising. 

Keywords: acne, gut-brain-skin axis microbiota, Polenoderm, diet