Natural modulation of the gut microbiota in patients with food allergies. Impact of Alergiplant
Major Gheorghe GIURGIU1, Prof dr med Manole COJOCARU2,3
1Deniplant-Aide Sante Medical Center, Biomedicine, Bucharest, Romania
deniplant@gmail.com; Telephone: +40 744 827 881
https://orcid.org/0000-0002-5449-2712
2Academy of Romanian Scientists
3Titu Maiorescu University, Faculty of Medicine, Bucharest, Romania
cojocaru.manole@gmail.com; Telephone: +40 723 326 663
https://orcid.org/0000-0002-7192-7490
Background Dysbiosis or microbial imbalance, can predispose individuals to allergies, while a balanced gut microbiome, fosters immune tolerance. The immune mechanisms involved in food allergies are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of food allergies.
Objective Alergiplant could modulate the immune system through gut microbiota in food allergies. Advancing knowledge of the gut microbiome and its function in modulating the course of food allergies, might result in novel therapeutic strategies.
Materials and methods The evaluation of the patients was based on history and physical examination. We investigated the effect Alergiplant in patients with food allergies.
Results Environmental factors such as urbanisation, pollution, and dietary habits also significantly contribute to food allergies risk. It is not clear whether microbial change in food allergies is an outcome of barrier defect or the cause of barrier dysfunction and inflammation. Manipulation of the gut microbiota as a method for modifying atopy, may be attempted in many ways including avoidance of certain foods, supplementation with probiotics and prebiotics, optimising nutrient intake, minimising stress, antimicrobial therapy, correction and prevention of low stomach acid, and faecal microbiota transplantation.
Conclusion The resident microbiota is important in maintaining structural and functional integrity of the gut and in immune system regulation. There was an increase of the intestinal permeability reported in patients with food allergies and a reduction of the gut microbiome diversity. Modifying gut microbiome by applying Alergiplant during early years may be a preventive and therapeutic option in high risk groups.
Keywords: food allergies, host-microbiome interaction; immune regulation; Alergiplant